Atomoxetine (Strattera)

Atomoxetine was the first non-stimulant medication approved for ADHD and is marketed as Strattera. Unlike stimulants, it acts selectively on the norepinephrine system with no significant effect on dopamine. That means it has a low potential for misuse and is not a controlled substance.

Atomoxetine has a cumulative effect — it takes 4 to 8 weeks to reach full effectiveness, unlike stimulants, which act within hours. It's indicated when stimulants haven't been effective, have caused unacceptable side effects, or when a co-occurring anxiety disorder is present that stimulants could worsen.

It's an important option for people with a history of substance use disorder, since it carries no misuse potential. It can also be especially effective for inattention and emotional impulsivity in ADHD.